Intraocular Pressure Reduction With the Bimatoprost/Timolol Fixed Combination

Larissa University Hospital30 enrolled

Overview

The purpose of this study is to examine the ocular hypotensive effect of Bimatoprost and the potential additional effect of the Bimatoprost/Timolol fixed combination in eyes with ocular hypertension, primary open angle glaucoma or exfoliation glaucoma.

Study Type

INTERVENTIONAL

Allocation

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Glaucoma Ocular Hypertension

Interventions

Bimatoprost and Bimatoprost/Timolol fixed combination.DRUG

Following an appropriate wash-out period, participants were given a 5-week long treatment with Bimatoprost 0.03% once daily in the evening followed by a further 5-week long treatment with the Bimatoprost 0.03%/Timolol 0.5% fixed combination administered in the evening.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Primary open angle glaucoma * Exfoliation glaucoma * Ocular hypertension Exclusion Criteria: * Younger than 18 years old * Inability to understand and/or follow study requirements * Women of childbearing potential not using reliable birth control, pregnant or lactating women * History of chronic obstructive pulmonary disease, heart failure, 2nd or 3rd AV block * Anticipated modification of treatment for systemic hypertension during the study period * History of ocular herpes, corneal scarring, conventional or laser surgery or macular pathology * History of allergy, poor tolerability or poor response to study medication * Best corrected visual acuity less than 0.4 * Significant visual field defect (MD\<15.0 dB)

Locations (1)

University Eye Clinic

Larissa, Thessaly, Greece

Outcomes

Primary Outcomes

Mean diurnal intraocular pressure

Time frame: Five weeks on each medication

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.