The purpose of this monocentric, preliminary study is to assess the evolution of pulmonary capillary blood volume (Vc), measured by the double diffusion nitric oxide/carbon monoxide (NO/CO) method (Guenard et al.; Respir Physiol 1987), from the starting of the anticoagulant therapy to 6 months after, and to search correlations with the evolution of clinical (dyspnea and results of the 6 minutes walking test), biological (BNP; Troponin), echocardiographic (right ventricular dysfunction, pulmonary arterial pressure) and ventilation/perfusion lung scan data.
Study Type
OBSERVATIONAL
Enrollment
50
pulmonary capillary blood volume (Vc), measured by the double diffusion NO/CO method: this method is to inhale during a deep inspiration with a mixture of helium (8-10%), CO (2000 ppm) and NO (20-40 ppm), the O2 (21%)
Departement of pneumology, CHU Saint-Etienne
Saint-Etienne, France
Department of Medicine and Therapeutic, CHU Saint-Etienne
Saint-Etienne, France
difference of pulmonary capillary blood volume (Vc) from J0 to 6 months
Time frame: from the starting of the anticoagulant therapy to 6 months after
correlations with the evolution of clinical (dyspnea and results of the 6 minutes walking test), biological (BNP; Troponin), echocardiographic (right ventricular dysfunction, pulmonary arterial pressure) and ventilation/perfusion lung scan data
Time frame: from the starting of the anticoagulant therapy to 6 months after
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