Lumbar puncture is one of the most common painful procedures performed on neonates in the Emergency Department (ED). The investigators will study in a randomized controlled trial, the efficacy of intravenous administration of a single dose of Midazolam in reducing pain and anxiety in neonates undergoing lumbar puncture in the ED, as well as the rate of adverse sedation reactions. The investigators hypothesize that compared with placebo, single dose Midazolam would significantly decrease pain and anxiety and will have low rate of adverse reactions.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
12
Intravenous infusion of 0.05 mg/kg of Midalolam
Rambam Health Care Campus
Haifa, Israel
The Simplified Neonatal Facial Coding System will be used for assessment of pain. Scoring will be composed from four specific facial actions (brow bulge, nasolabial furrow, eye squeeze, and open mouth) and the presence or absence of crying
Time frame: 20 seconds prior lumbar puncture, during needle insertion, and 20 seconds post insertion
Physician's level of satisfaction from the procedural conditions
Time frame: Five minutes post successful LP
LP Success rate
Time frame: Five minutes post successful LP
Adverse sedation reactions
Time frame: During procedure and during recovery phase
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