Effects of Liquid Zinc Supplementation and Dispersible Zinc Tablets on Plasma Zinc Concentration

University of California, Davis462 enrolled

Overview

The study aims to compare the effects of two different formulations of zinc supplements on plasma zinc concentrations among young Burkinabe children.

1\) To investigate the effects of short-term zinc supplementation, provided either as a dispersible tablet containing zinc sulfate ("ZinCfant," Nutriset Ltd; Malaunay, France) or as a liquid ZnSO4 solution, on changes in serum zinc concentration, compared with a placebo in young Burkinabe children; and 2) to assess the relationship between change in serum zinc concentration and the presence of altered intestinal permeability within each treatment group.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

QUADRUPLE

Enrollment

462

Conditions

Zinc Deficiency

Interventions

Liquid zinc syrupDIETARY_SUPPLEMENT

Liquid zinc syrup containing 5 mg zinc as zinc sulfate

Zinc tabletDIETARY_SUPPLEMENT

Dispersible zinc tablet containing 5 mg zinc

Liquid placebo supplementDIETARY_SUPPLEMENT

Liquid placebo supplement containing 0 mg zinc

Eligibility

Sex: ALLMin age: 6 MonthsMax age: 23 MonthsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * currently breast feeding * informed consent of a parent or guardian. Exclusion Criteria: * symptomatic acute or chronic febrile infections * diarrhea within the past week * consuming vitamin or mineral supplements or zinc-fortified infant formulas

Locations (1)

Toussiana Health District

Touziana, Burkina Faso

Outcomes

Primary Outcomes

Plasma zinc concentration

Time frame: 3 weeks

Data from ClinicalTrials.gov

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