Allogeneic Stem Cell Transplantation in Pediatric Patients With Malignant and Non-malignant High-risk Diseases

Inclusion Criteria: * Patients aged 0 to 30 years * Written informed consent from patient and/or parents or guardian * Patients with Karnofsky Index \> 60% * Malignant disease: * acute lymphoblastic leukemia * acute myeloid leukemia * myelodysplastic syndrome * chronic myeloid leukemia according to the standard indications * solid tumors (e.g. neuroblastoma recurrence, soft-tissue sarcoma, Ewing's sarcoma, osteosarcoma, hepatoblastoma) . Non malignant disease: * acquired anemias (e.g. severe aplastic anemia, particularly severe Evans syndrome) * congenital anemias (e.g. thalassemia and sickle cell anemia) * Women reliable contraception method when appropriate Exclusion Criteria: * Participation in other clinical trials * Patients, parents, or guardians unable to understand the nature, the importance and the implications of the procedure * Pregnant or nursing women * Patients who underwent a stem cell transplantation in the last 250 days * Patients with kidney, heart or liver insufficiency