Citrate Pharmacokinetics and Regional Citrate Anticoagulation in CRRT

Huashan Hospital40 enrolled

Overview

1. To compare the differences of citrate pharmacokinetics in healthy individuals and critically ill patients as well as the influential factors. 2. To validate a pharmacokinetic model which has been established in a formal paper. 3. To create a safe and effective RCA-CRRT protocol.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Acute Kidney Failure With or Without:MODS Sepsis Hepatic Insufficiency

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * healthy individuals, none-pregnant * diagnosed with acute renal failure according to RIFLE criteria * ARF with hepatic insufficiency * ARF with MODS or sepsis * within informed consent Exclusion Criteria: * used drugs with citrate within one week * infused with blood,plasma or platelet or undergone plasma exchange therapy within 48 hours * serious alkalosis with PH\>7.55 * serious lactic acidosis * not in resuscitation state

Locations (1)

Huashan hospital

Shanghai, China

RECRUITING

Central Contacts

Feng Ding, Professor

CONTACT

86-02152888135 ding_feng@hotmail.com

Data from ClinicalTrials.gov

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