Effects of Chantix on Relapse Prevention for Smoking Cessation

Inclusion Criteria: * Eligible participants will be 68 (34 male and 34 female) smokers aged 18-65, who smoke ≥ 10 cigarettes per day, provide a baseline CO reading ≥ 10 ppm and who plan to live in the area for the next 6-months. Exclusion Criteria: * Smoking Behavior 1. Use of chewing tobacco or snuff 2. Current enrollment or plans to enroll in another smoking cessation program in the next 5 months 3. Plan to use other nicotine substitutes or smoking cessation treatments in the next 5 months 4. Provide a baseline CO reading \< 10 ppm Alcohol/Drug Exclusion Criteria 1. History of substance abuse and/or currently receiving treatment for substance abuse (e.g., alcohol, opioids, cocaine, marijuana, or stimulants) 2. Current alcohol consumption that exceeds \>25 standard drinks/week Medication Exclusion Criteria 1\. Current use or recent discontinuation (within last 14-days) of the following medications: 1. Any form of smoking cessation medication (zyban, wellbutrin, wellbutrin SR, Chantix, NRT) 2. Any form of anti-psychotic medications that includes: * antipsychotics, * atypical antipsychotics, * mood-stabilizers, * anti-depressants (tricyclics, SSRI's, MAOI's), * anti-panic agents, * anti-obsessive agents, * anti-anxiety agents, and * stimulants (e.g., Provigil, Ritalin). 3. Medication for chronic pain 4. Anti-coagulants 5. Any heart medications 6. Daily medication for asthma Medical Exclusion Criteria 1. Women who are pregnant, planning a pregnancy, or lactating. 2. History or current diagnosis of psychosis, major depression or bipolar disorder, schizophrenia, or any Axis 1 disorder as identified by the SCID. 3. Serious or unstable disease within the past 6 months (e.g., cancer \[except melanoma\], heart disease, HIV). 4. History of epilepsy or a seizure disorder. 5. History or current diagnosis (last 6-months) of abnormal rhythms and/or tachycardia (\>100 beats/minute); history or current diagnosis of COPD, cardiovascular disease (stroke, angina, coronary heart disease), heart attack in the last 6 months, uncontrolled hypertension (SBP\>150 or DBP\>90) 6. History of Kidney and/or liver failure (including transplant). 7. Wears a device to aid in hearing (hearing aid, cochlear implant, etc.). 8. Hearing threshold \< 40 dB SPL at 1000 Hz. 9. Color blindness. General Exclusion 1. Any medical condition or concomitant medication that could compromise participant safety or treatment, as determined by the Principal Investigator and/or Study Physician. 2. Inability to provide informed consent or complete any of the study tasks as determined by the Principal Investigator and/or Study Physician. 3. Any physical or visual impairment that may prevent the individual from using a computer keyboard or completing any study tasks.