To evaluate changes in platelet counts and hemodynamics between "rapid" and "long" platelet infusion groups.
1. It is our hypothesis that the change in post-transfusion platelet counts of babies who receive platelets over 30 minutes (short transfusion group) will be significantly different from the change in babies who receive platelets over two hours (long transfusion group) when platelets are checked immediately after transfusion and 6 hours after the completion of transfusion. 2. We also expect there to be significant differences in the platelet counts drawn thirty minutes after transfusion compared to the counts drawn 6 hours after the completion of the transfusion in either group.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
21
15cc/kg of non-centrifuged, non-refrigerated, leukoreduced, AB-negative pheresis platelets administered over 30 minutes
15cc/kg of non-centrifuged, non-refrigerated, leukoreduced, AB-negative pheresis platelets given over two hours.
Children's Hospital of Oklahoma
Oklahoma City, Oklahoma, United States
Change in Post-transfusion Platelet Counts
The difference between the baseline platelet count and the platelet count taken 30 minutes after completion of the transfusion.
Time frame: Baseline-30 minutes after transfusion
Change in Post-transfusion Platelet Counts
The difference between the baseline platelet count and the platelet count taken 6 hours after completion of the transfusion.
Time frame: Baseline - 6 hours after transfusion
30 Minute-6 Hour Difference in Platelet Counts
Time frame: 30 minutes - 6 hours after transfusion
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