This study was designed to evaluate the ability of gonadotropin releasing hormone (GnRh) agonist to prevent the rise of progesterone during controlled ovarian stimulation for in vitro fertilization (IVF) after the administration of human Chorionic Gonadotropin (hCG) on the first day of menses.
The aim of this study is to evaluate the efficacy of a GnRH agonist in preventing the functional rescue of corpus luteum in women submitted to controlled ovarian stimulation with administration of hCG on the first day of menses and to evaluate its effect on pregnancy rate and ovarian steroidogenesis.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
25
3,6mg of goserelin acetate, 250mg of hCG, FSH variable dose according to the number of days required for appropriate ovarian stimulation
250mg of hCG, Zoladex, FSH variable dose according to the number of days required for appropriate ovarian stimulation
Assisted Reproduction Center "Governor Mário Covas" of the Faculty of Medicine of the University of São Paulo
São Paulo, São Paulo, Brazil
RECRUITINGFrequency of functional rescue of corpus luteum
Time frame: 6 months
Pregnancy rate
Time frame: 6 months
Levels of serum steroids
Time frame: 6 months
Levels of serum gonadotropins
Time frame: 6 months
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