Measuring Responses to Sublingual Antigens

Inclusion Criteria: * A female adult volunteer aged between 18 and 35 years old. * Subjects who the investigator believes can and will comply with the requirements of the protocol. * Provide written informed consent following a detailed written explanation of participation in the protocol. * They are in good health as determined by medical history, physical examination, haematology testing, and clinical judgement before entering into the study. * They are available for the whole duration of the study. * If of childbearing potential, must have a negative pregnancy test before each immunisation. * They have not donated blood during 3 months prior to study entry and agree to not donate for 3 months after the end of their participation in the study. * They are eligible for free medical treatment Exclusion Criteria: * They have already been vaccinated with an HPV vaccine * They have participated in a clinical trial in the last 6 months in which they have been exposed to an investigational product (pharmaceutical product or placebo or device) or concurrent participation in another clinical research study at the time of enrolment. * Use of any investigational or non-registered product (drug or vaccine) within 30 days preceding the first dose of challenge agent, or planned use during the study period. * They are pregnant or breast-feeding. * They have a known or suspected ongoing cervico-vaginal disease, malignancy or abnormality discovered at time of screening. * They present in the samples obtained at the screening visit: positive results for HIV, HBs Ag, anti-HBc and anti-HCV antibody, a clinically significant abnormality in haematology. Normal ranges will be defined by the pathology laboratory undertaking assays. * They have a clinically significant acute or chronic pulmonary, cardiovascular, hepatic or renal functional abnormality, blood or neurological disorders, immune dysfunction, autoimmune diseases, diabetes (excluding history of gestational diabetes), or malignancy at the time of enrolment, as determined by medical history, physical examination or laboratory screening tests. * They have received any form of immunosuppressive therapy in the past 6 months. * They are receiving any medications via vaginal route (as this may interfere with collection of samples). * They have any tongue or frenulum piercings or oral jewellery that may interfere with sublingual delivery. * They have received blood products or immunoglobulins 120 days prior to enrolment. * They have thrombocytopaenia or any coagulation disorder (because bleeding may occur following an intramuscular administration in these individuals). * Any other medical, psychiatric or social condition, drug treatment, occupational or other responsibility that, in the judgement of the investigator, would interfere with or serve as a contradiction to adherence to the study protocol or ability to give informed consent. * Individuals who cannot read or speak fluent English.