Apitox, Honeybee Venom Treatment for Osteoarthritis Pain and Inflammation

Inclusion Criteria: * osteoarthritis of one or both knees * on stable NSAID or none due to intolerance * women either post menopausal or on stable birth control * no clinically significant disease or or abnormal laboratory values * signed informed consent, communicate effectively, understand and comply with all study requirements Exclusion Criteria: * serious or unstable medical or psychological condition * known sensitivity to honeybee venom, histamine or lidocaine * history of asthma * any clinically significant ECG abnormalities * any clinically significant laboratory values OOR * history of drug or alcohol abuse * history of joint injury and forms of inflammatory arthritis