Exercise, Oxidative Stress and HIV

N/ACompletedNCT00950937

Hospital de Clinicas de Porto Alegre28 enrolled

Overview

The purpose of this study is to compare oxidative stress markers and the immunologic characteristics of HIV-infected and non-HIV subjects during a bout of moderate aerobic exercise followed by resistance exercises

Study Type

OBSERVATIONAL

Enrollment

28

Conditions

Eligibility

Sex: ALLMin age: 20 YearsMax age: 55 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * HIV Group:without contraindications for exercise training; to highly active antiretroviral therapy (HAART) for at least 6 months before enrollment; be classified as low level of physical activity by international physical activity questionnaire (IPAQ) and did not use antioxidant supplements. * Control Group:negative result for HIV-1 test and the other criteria described above Exclusion Criteria: * Subjects with previous history of cardiovascular and neurological disease, diabetes, dyslipidemia, tobacco using, physical disability and pregnant women were excluded from the study.

Locations (1)

Outpatient HIV/AIDS care unit of the Hospital de Clínicas de Porto Alegre

Porto Alegre, Rio Grande do Sul, Brazil

Outcomes

Primary Outcomes

Total Glutathione

The total glutathione content in erythrocyte concentrate at three moments: baseline, aerobic and resistance exercise.

Time frame: 3 times - baseline (before the peak oxygen uptake test), aerobic (immediately after aerobic exercise) and resistance (immediately after resistance exercise).

Secondary Outcomes

Catalase Activity

Antioxidant activity of the catalase enzyme at three moments: baseline, aerobic and exercise.

Time frame: 3 times - baseline (before the peak oxygen uptake test), aerobic (immediately after aerobic exercise) and resistance (immediately after resistance exercise).

Glutathione S-transferase (GST)

Antioxidant activity of the Glutathione S-transferase enzyme at three moments: baseline, aerobic and resistance exercise.

Time frame: 3 times - baseline (before the peak oxygen uptake test), aerobic (immediately after aerobic exercise) and resistance (immediately after resistance exercise).

Lipid Peroxidation

Thiobarbituric acid-reactive substances (TBARS) assay was used as an index of lipid peroxidation in erythrocytes, at three moments: baseline, aerobic and resistance exercise.

Time frame: 3 times - baseline (before the peak oxygen uptake test), aerobic (immediately after aerobic exercise) and resistance (immediately after resistance exercise).

T CD4

T CD4 lymphocytes counts at three moments: baseline, aerobic and resistance exercise.

Time frame: 3 times - baseline (before the peak oxygen uptake test), aerobic (immediately after aerobic exercise) and resistance (immediately after resistance exercise).

Neutrophil Count

Neutrophil count at three moments: baseline, aerobic and resistance exercise.

Data from ClinicalTrials.gov

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NCT00950937 - Exercise, Oxidative Stress and HIV | Crick | Crick