Dose-response Enteral Citrulline for Normal Healthy Volunteers and Surgery Patients

Société des Produits Nestlé (SPN)14 enrolled

Overview

To determine the level of citrulline to produce a given amount of arginine in healthy volunteers and surgical patients. Arginine-related amino acids are expected to increase as a result of increased substrate provided by citrulline.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

QUADRUPLE

Enrollment

Conditions

Nutritional Deficiency

Interventions

citrullineOTHER

TID for 5 days

LemonadeOTHER

TID for 5 days

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * adults, male \& female, non-pregnant * BMI 18.5-29.9 Exclusion Criteria: * cancer * HIV positive

Locations (1)

University of Pittsburgh Medical Center

Pittsburgh, Pennsylvania, United States

Outcomes

Primary Outcomes

Plasma amino acid levels

Time frame: 8 hours

Data from ClinicalTrials.gov

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