Evaluation of Alteration by Magnetic Resonance Imaging (MRI) in Dementia Among Elderly Subjects

University Hospital, Bordeaux318 enrolled

Overview

Capturing the earliest stages of Dementia especially Alzheimer's Disease (AD) is a great challenge. Until now the NINCDS-ADRDA and the DSM criteria for AD were largely used as diagnostic standards in research. However, the research on AD progresses and some biomarkers have been recently suggested to improve the diagnostic criteria of AD, such as cerebrospinal fluid markers, neuroimaging with Positon Emission Tomography (PET) or Magnetic Resonance Imaging (MRI).

Study Type

OBSERVATIONAL

Enrollment

318

Conditions

Dementia Alzheimer Disease

Interventions

NeuroimagingOTHER

Three successive MRI acquisitions to measure FA, MTR and T2 parameters.

Eligibility

Sex: ALLMin age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * participate in the AMI cohort * be aged 65 and older * be retired from agricultural profession * live in rural area in Gironde Exclusion Criteria: * contraindication of MRI * left-handed * severe dementia * Parkinson's disease * poor health incompatible with the transport to neuroimaging service * to be left handed

Locations (1)

Groupe Hospitalier Pellegrin - C.H.U. de Bordeaux

Bordeaux, France

Outcomes

Primary Outcomes

FA (Fractional Anisotropy), MTR (magnetization transfer ratio) and T2 (Transverse relaxation time) measures in patients with dementia compared to controls, in left and right hippocampus, and posterior cingulum

Time frame: day 0

Secondary Outcomes

FA, MTR and T2 measures in subjects with mild cognitive impairment no dementia

Time frame: day 0

Performances in the 7 neuropsychological tests available in the AMI cohort

Time frame: day 0

FA measures for the connexion Hippocampus-cingulum posterior

Time frame: day 0

Data from ClinicalTrials.gov

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