The Effect of Welchol on Glucose Metabolism in Type 2 Diabetics

Inclusion Criteria: * Age 35-70 years old. * Body Mass Index greater than 19kg/m\^2 or less than 40kg/m\^2 or a total weight less than 130 kilograms. * Negative pregnancy test for women of childbearing potential. * Absence of gastrointestinal symptoms. * Signed informed consent. * Treatment with diet and/or metformin. Subjects must be on stable therapeutic doses of metformin and/or lipid-lowering agents for more than 3 months. Exclusion Criteria: * Structural or metabolic diseases/conditions that affect the gastrointestinal system, or functional gastrointestinal disorders. A screening Bowel Disease Questionnaire will be used to exclude subjects with irritable bowel syndrome. Patients with a history of dysphagia or intestinal motility disorders will be excluded. * Prior history of pancreatitis. * Prior history of hypertriglyceridemia (500mg/dL or greater). * Currently using a bile-acid binding resin such as colesevelam, colestipol, colestimide or cholestyramine. * To ensure homogeneity between treatment groups we will exclude subjects with insulin-treated type 2 diabetes mellitus, subjects who have received an inhibitors of dipeptidyl peptidase 4 (DPP-4 inhibitors) or "gliptins" (a class of oral hypoglycemics), Byetta or sulfonylurea agent in the past three months. * HbA1c greater than 9.0%. * Patients who have not been stable on all medications for a period exceeding 3 months. * Use of drugs or agents within the past 2 weeks or planned use in the subsequent 4 weeks during the study period that: * Alter GI transit including laxatives, magnesium or aluminum-containing antacids, prokinetics, erythromycin, narcotics, anticholinergics, tricyclic antidepressants, Selective Serotonin Reuptake Inhibitors (SSRIs) and newer antidepressants. * Opiate-based analgesic drugs (Note: intermittent or chronic use of aspirin or non-steroidal anti-inflammatory drugs (NSAID) will be allowed). * Antihistamines * Anticholinergic agents * Female subjects who are pregnant or breast-feeding. Females must be either surgically sterilized, postmenopausal (\>12 months since last menses), or, if of childbearing potential, using reliable methods of contraception as determined by the physician. * Clinical evidence (including physical exam and Electrocardiogram) of significant cardiovascular, respiratory, renal, hepatic, gastrointestinal, hematological, neurological, psychiatric, or other disease that interfere with the objectives of the study. Any candidate participants with such disorders mentioned will be referred to their general physician.