A randomized placebo controlled trial evaluating the effect of the recently recommended high doses of cholecalciferol (3000 IU/day) on mineral metabolism, blood pressure and pulse wave analysis in healthy individuals.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
40
Capsule cholecalciferol 1000 IU, 3 capsules per day for 16 weeks
Empty capsules, 3 capsules per day for 16 weeks
Roskilde Hospital
Roskilde, Roskilde, Denmark
urinary calcium excretion
Time frame: before and after 16 weeks of intervention
25 hydroxyvitamin D
Time frame: before and after 16 weeks og treatment
1,25 dihydroxyvitamin D
Time frame: before and after 16 weeks of treatment
urinary creatinin
Time frame: before and after 16 weeks of treatment
urinary protein
Time frame: before and after 16 weeks of treatment
urinary phosphorous
Time frame: before and after 16 weeks of treatment
p-FGF23
Time frame: before and after 16 weeks of treatment
blood pressure
Time frame: before and after 16 weeks of treatment
pulse wave velocity
Time frame: before and after 16 weeks of treatment
augmentation index
Time frame: before and after 16 weeks of treatment
central blood pressure
Time frame: before and after 16 weeks of treatment
p-phosphate
Time frame: before and after 16 weeks of treatment
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ionised p-calcium
Time frame: before and after 16 weeks of treatment
p-iPTH
Time frame: before and after 16 weeks of treatment
alkalic phosphatase
Time frame: before and after 16 weeks of treatment