A Comparative Study of Ampicillin/Sulbactam Versus Moxifloxacin in the Treatment of Complicated Intra-abdominal Infections

Kaohsiung Medical University Chung-Ho Memorial Hospital100 enrolled

Overview

On the basis of monotherapy for intra-abdominal infection, the investigators are conducting this study to identify the difference of drug efficacy between ampicillin/sulbactam and moxifloxacin.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

100

Conditions

Intra-abdominal Infection

Interventions

moxifloxacinDRUG

moxifloxacin 400mg once daily (IV form, 60minutes)

ampicillin/sulbactamDRUG

ampicillin/sulbactam 1.5g 4 times daily (IV form, administered 60minutes)

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: * patients diagnosed of complicated intra-abdominal infection need surgical treatment Exclusion Criteria: * patients diagnosed of intra-abdominal infection receive non-operative management * patients with known allergic history of fluoroquinolone * Severe, life threatening disease with a life expectancy of \< 48 h or APS and APACHE scores of \> 35

Locations (1)

Kaohsiung Medical University Hospital, Department of Emergency Medicine/Surgery

Kaohsiung, Taiwan, Taiwan

Outcomes

Primary Outcomes

clinical response at test-of-cure visit

Time frame: test of cure: 10-14 days after initial treatment

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.