Effects of Prednisolone and Infliximab on the Regulation of Urea Synthesis in Active Inflammatory Bowel Disease

University of Aarhus40 enrolled

Overview

Loss of total mass of muscles (catabolism) is a serious clinical problem in patients with active inflammatory bowel disease (IBD). The investigators have earlier shown that the liver plays an important role in this stress-catabolism by increasing the production of urea during the inflammatory process. The purpose of this study is to examine the effect of the anti-inflammatory drugs prednisolone and infliximab on the regulation of the urea synthesis in patients with active ulcerative colitis and Crohn's disease.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Inflammatory Bowel Diseases

Eligibility

Sex: ALLMin age: 18 YearsMax age: 50 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Moderate to severe active inflammatory bowel disease Exclusion Criteria: * Viral or bacterial infections * Other chronical inflammatory diseases * Cancer * Other catabolic diseases * Treatment with prednisolone or infliximab within the last 8 weeks

Locations (1)

Department of Medicine V, Aarhus University Hospital

Aarhus, Denmark

Outcomes

Primary Outcomes

Functional Hepatic Nitrogen Clearance

Time frame: Before and one week after treatment

Secondary Outcomes

Clinical and biochemical measures of inflammation

Time frame: Before and one week after treatment

Data from ClinicalTrials.gov

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