Efficacy and Safety Study of Glucosamine/Chondroitin Sulfate to Patients Treatment With Osteoarthrosis of the Knee

Inclusion Criteria: * Subjects have to read and sign the approved the Informed Consent form prior to any participation in the study. * Male or female Subjects, aged upper to 40 years. * Osteoarthritis of the knee confirmed by radiological examination. * Visual analogue scale (VAS) \> 40 mm. * Kellgren and Lawrence grade 1 to 3. * Clinical diagnosis of pain and functional limitation. Exclusion Criteria: * History of significant trauma or surgery in the affected joint. * Pregnant women, lactating or not using appropriate contraceptive method. * History or presence of active rheumatic disease that may be responsible for secondary osteoarthritis. * Severe inflammation of the joint confirmed by physical examination (excluding also erythrocyte sedimentation \<40mm/h and rheumatoid factor \<1:40). * Body mass index \> 30. * Hematologic abnormalities, liver, renal or metabolic functions which undermine the serious participation of the patient (at investigator's criteria). * Systemic administration and/or intra-articular corticosteroids in the last 3 months. * Have made use of glucosamine and/or chondroitin. * Lequesne index of \> 12. * Arthroplasty in the affected joint. * Use of narcotic analgesics. * Any condition that, in the opinion of the investigator, renders the patient unable to participate in the study.