Comparison of Low Fat and Low Carbohydrate Diets With Respect to Weight Loss and Metabolic Effects

Inclusion Criteria: * Body Mass Index \> 27 kg/m2 * No chronic medication (except oral contraceptives and L-Thyroxine) or possibility to stop medication for study duration * Able to give written informed consent Exclusion Criteria: * Pregnancy and nursing * Severe cardiovascular, liver, kidney, hepatic or orthopedic disease that need treatment * Metabolic or endocrine disease that need treatment * Hypertension blood pressure \> 160/95 mmHg or need of \> 2 drugs * Previous stroke or cerebral ischemia * Significant neurologic or psychiatric disease * Any kind of eating disorder * Bariatric surgery in the past * Drug or alcohol abuse * Any cancer in the past * Acute and chronic infections * Metallic implants (e.g. pace makers) or conditions that do not allow MRI scans * Body weight \> 130 kg