Analgetic Effect of Preoperative Pregabalin in Patients Undergoing Nephrectomy

Medical University of Graz20 enrolled

Overview

Pregabalin 300mg or placebo are administered 1 hour preoperatively in patients undergoing elective nephrectomy. Postoperatively, patients receive a patient controlled analgesia device for self delivering opioids. Morphine consumption in the first 48 hours is documented. Hyperalgesia is measured by von-Frey-Filaments.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

TRIPLE

Enrollment

Conditions

Postoperative Pain

Interventions

PregabalinDRUG

300mg pregabalin orally 1 hour before operation

PlaceboDRUG

Placebo

Eligibility

Sex: ALLMin age: 18 YearsMax age: 70 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * patients undergoing elective nephrectomy Exclusion Criteria: * contraindication against pregabalin * creatinine \> 2.0 mg/dl * GGT \>165, AST \>105, ALT \>135 * peptic Ulcus * haemorrhagic diathesis * angina pectoris, myocardial infarction * stroke * bronchial asthma * opioid abuse

Locations (1)

Medical University of Graz

Graz, Austria

Outcomes

Primary Outcomes

postoperative opioid consumption

Time frame: 48 hours

Data from ClinicalTrials.gov

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