Treatment of Cocaine Dependence With Lisdexamfetamine

Inclusion Criteria: * Eligible participants must: 1. Be treatment-seeking males or females between 18 and 65 years-of-age; 2. Understand the study procedures and provide written informed consent; 3. Be judged by the examining physician to be in generally good health with the exception of health problems related to acute drug use; 4. Meet DSM-IV criteria for cocaine-dependence. Exclusion Criteria: * Exclusion criteria include: 1. DSM-IV diagnoses for current psychotic disorders, mood disorders (except substance-induced depression), anxiety disorders, ADHD, and other current substance dependence (except marijuana and nicotine dependence); subjects may not have physiological dependence upon alcohol requiring medical detoxification; 2. Current use of any prescription medications; 3. Females currently pregnant or nursing; 4. Current elevation of liver enzyme levels above twice normal limits; 5. Existing cardiovascular disease as determined by physician, EKG evaluation; 6. History of significant acute or chronic physical illness precluding participation; 7. History of hyperthyroidism, glaucoma, or seizures.