Research suggests dietary fiber may play a role in weight management, and fiber consumption is inversely associated with body weight, body fat, and BMI in cross-sectional studies. These effects may be mediated by increased satiety, reduced food intake, or changes in blood levels of glucose, insulin, and gut hormones. The purpose of this study is to determine the satiety, glycemic, hormonal, and gastrointestinal responses of novel fiber supplements.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Masking
QUADRUPLE
Enrollment
20
Low fiber muffin, hot cereal and beverage (acute phase) or fiber bars and beverage (chronic phase)
25 g resistant starch, administered in a muffin, hot cereal and beverage (acute phase) or fiber bars and beverage (chronic phase)
25 g fiber as resistant starch and a soluble fiber, administered in a muffin, hot cereal and beverage (acute phase) or fiber bars and beverage (chronic phase)
University of Minnesota - General Clinical Research Center
Minneapolis, Minnesota, United States
Satiety
Time frame: 0, 15, 30, 45, 60, 90, 120, 180, 215 minutes postprandially
ad libitum food intake
Time frame: 180 minutes postprandially and over 24 hours
Ghrelin, polypeptide YY (PYY), and glucagon-like peptide-1 (GLP-1) response
Time frame: 0, 30, 60 minutes postprandially
Gastrointestinal tolerance and fecal chemistry
Time frame: following 7 days of treatment
Glucose/Insulin Response
Time frame: 0, 15, 30, 45, 60, 90, 120, 180 minutes postprandially
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25 g fiber made from corn starch, administered in a muffin, hot cereal and beverage (acute phase) or fiber bars and beverage (chronic phase)
25 g fiber as a fiber made from corn starch and a soluble fiber, administered in a muffin, hot cereal and beverage (acute phase) or fiber bars and beverage (chronic phase)