Effect of Thiamphenicol on EAAT2 and Other Biomarkers From Nasal Biopsied Tissue

Psyadon Pharma30 enrolled

Overview

The purpose of this study is to determine if two-weeks of dosing with thiamphenicol is safe and is able to change the levels of certain pre-specified biomarkers in nervous tissue taken from the nasal passages.

Thiamphenicol has been proposed to increase the levels of the excitatory amino acid transporter 2 (EAAT2) in the nervous tissue. This study evaluated the ability of two weeks of treatment with thiamphenicol to increase EAAT2 in a nasal biopsy as a surrogate of brain nervous tissue.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

QUADRUPLE

Enrollment

Conditions

Healthy

Interventions

ThiamphenicolDRUG

750 and 1500 mg/day;tablets

PlaceboDRUG

Matched tablets without active ingredient

Eligibility

Sex: ALLMin age: 18 YearsMax age: 55 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * normal volunteers Exclusion Criteria: * less than 18 years * older than 55 years

Locations (1)

SGS Research Unit - Stuivenberg

Antwerp, Belgium

Outcomes

Primary Outcomes

Amount of EAAT2 RNA in nasal biopsy

Time frame: Two weeks

Data from ClinicalTrials.gov

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