The Effect of Vitamin K Supplementation on Glucose Metabolism

Seoul National University Hospital42 enrolled

Overview

The purpose of this study is to test whether vitamin K supplementation has an effect on glucose metabolism in terms of acute beta cell response.

Recently, many studies have reported that vitamin K metabolism is related to glucose metabolism. The suggested mechanisms connecting vitamin K metabolism and glucose metabolism, are inflammation responses and osteocalcin effect on glucose metabolism. Most of the studies have investigated fasting glucose and insulin sensitive index, few have assessed glucose-intake-stimulated responses in regard to vitamin K supplementation. The purpose of this study is to test whether vitamin K supplementation has an effect on glucose metabolism in terms of acute beta cell response using intravenous glucose tolerance test.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Diabetes Prediabetic State

Interventions

MenatetrenoneDRUG

Menatetrenone 30 mg, 3 times a day for 4 weeks

PlaceboDRUG

Placebo

Eligibility

Sex: MALEMin age: 20 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy male volunteer older than 20 years Exclusion Criteria: * Subjects with (a history of) diabetes * Subjects receiving medication related to diabetes or obesity * Subjects receiving warfarin

Locations (1)

Seoul National University Medical School

Seoul, South Korea

Outcomes

Primary Outcomes

AIRg (acute insulin response to glucose) using FSIGT (frequently sampled intravenous glucose tolerance test)

Time frame: 4 weeks later

Secondary Outcomes

beta-cell function (FSIGT)

Time frame: 4 weeks later

disposition index (FSIGT)

Time frame: 4 weeks later

insulin sensitivity (FSIGT)

Time frame: 4 weeks later

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.