Study of LX4211 in Subjects With Type 2 Diabetes Mellitus

Inclusion Criteria: * Males and females (non-childbearing potential), aged 18-65 years * Diagnosis of Type 2 diabetes mellitus for at least 6 months prior to screening * Fasting plasma glucose ≤ 240 mg/dL prior to metformin washout * Body mass index \< 42 kg/m\^2 * HbA1c value of 7 to 11% * C-peptide ≥ 1.0 ng/mL * Ability to provide written informed consent Exclusion Criteria: * History of Type 1 diabetes mellitus, diabetic ketoacidosis, hyperosmolar nonketotic syndrome, incontinence, or nocturia * Use of any blood glucose lowering agent other than metformin * Prior exposure to insulin, thiazide, or loop diuretics within 4 weeks prior to screening * Laboratory or electrocardiogram abnormalities deemed significant by the Sponsor or the Investigator * Positive test result for glutamic acid decarboxylase (GAD) antibody * Surgery within 6 months of screening * Exposure to any investigational agent or participation in any investigational trial within 30 days prior to Day 1 * Hypersensitivity to an SGLT2 inhibitor * History of drug or alcohol abuse within the last 12 months