Study to Evaluate the Effect of Bimosiamose on Ozone Induced Sputum Neutrophilia

Inclusion Criteria: * Able to produce sputum with normal sputum neutrophil levels at screening (\< 65% of non-epithelial cells). * Ozone responsive, defined as ≥ 20% relative increase in sputum neutrophils cell count after 3 h ozone challenge. * At screening FEV1 at least 80% of predicted. Exclusion Criteria: * Smokers (use of tobacco products in the previous 3 months). Urine cotinine levels will be measured during screening for all subjects. Smokers will be defined as any subject who reports of a recent tobacco use and/or who has a urine cotinine ≥ 500 ng/mL. * Significant illness within two weeks prior to dosing (e.g., infection). * Recent (within the last three years) and/or recurrent history of acute or chronic bronchospastic disease (including asthma and chronic obstructive pulmonary disease, treated or not treated).