RATIONALE: Panobinostat and everolimus may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the cancer. Giving panobinostat together with everolimus may kill more cancer cells. PURPOSE: This phase I trial is studying the side effects and best dose of panobinostat when given together with everolimus in treating patients with relapsed or refractory lymphoma or multiple myeloma.
OBJECTIVES: Primary * To evaluate the safety and feasibility of combining panobinostat with everolimus in patients with recurrent or refractory lymphoma or multiple myeloma. * To define the maximum tolerated dose of panobinostat in combination with everolimus in these patients. Secondary * To obtain preliminary data for response to this treatment regimen in these patients. * To perform correlative studies relevant to this treatment regimen. OUTLINE: This is a dose-escalation study of panobinostat. Patients receive oral panobinostat 3 days a week and oral everolimus once every other day for 4 weeks Courses repeat every 4 weeks in the absence of disease progression or unacceptable toxicity. Blood and bone marrow samples may be collected for pharmacokinetic and correlative laboratory studies. After completion of study treatment, patients are followed up for ≥ 4 weeks.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
11
Beginning with 5 mg every other day Monday, Wednesday or Friday for a 28 day cycle. Dose escalation will be determined by the toxicities associated with treatment.
10 mg every Monday and Thursday of a 28 day cycle. Dose escalation will be determined by the toxicities associated with treatment.
Pre-study, day 1 and day 26 samples to evaluation how the study drugs work in vitro (in a test tube).
City of Hope Medical Center
Duarte, California, United States
City of Hope Medical Group
Pasadena, California, United States
Maximum tolerated dose
Time frame: 90 days post treatment start
Toxicity
Time frame: 90 days post treatment start
Pharmacokinetic and correlative studies
Time frame: Day 1 and Day 26 of the first cycle of treament
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Pre-study, day 1 and day 26