Image-Guided Tumorboost of Bladder Cancer

University of Aarhus19 enrolled

Overview

The purpose of the study is to increase the radiation dose (Boost) to the bladder tumor. The bladder cancer patients included in the study will undergo tumor demarcation. The bladder demarcations will then be the target for an image-guided boost delivered precisely to the expected tumor site.

Study Type

INTERVENTIONAL

Allocation

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Bladder Neoplasms

Interventions

Radiation boostRADIATION

Radiation boost of the bladder-tumor: 10 Gy/5 fractions, 2 Gy per fraction.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Muscle invasive bladder cancer (transitional carcinoma) * Unifocal * TNM stage T2a-4a, N0-1, M0 * unfit for radical cystectomy Exclusion Criteria: * Hyperthyroidism * Multinodular goiter * Pregnancy * Breast feeding * WHO preformance status more than 2 * Iodine allergy * MRI or CT contrast media allergy * Bi-lateral hip-prosthesis

Locations (4)

The department of Oncology, Aarhus University Hospital

Aarhus, Denmark

The department of Oncology, Rigshospitalet

Copenhagen, Denmark

The department of Oncology, Herlev University Hospital

Herlev, Denmark

The department of Oncology, Odense University Hospital

Odense, Denmark

Outcomes

Primary Outcomes

Local tumor control

Time frame: One year

Secondary Outcomes

Acute and late adverse effects of the radiotherapy treatment

Time frame: 3 years

Data from ClinicalTrials.gov

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