Validation Study of Multiple Probe Compounds for Drug Interaction Evaluation

Inclusion Criteria: * Healthy as determined by a responsible physician * Subjects are not poor metabolizers based on genotyping for the major CYP2C9, 2C19, 2D6 alleles * Male or female between 20 and 50 years of age at the time of screening, inclusive. * A female subject is eligible to participate if she is of Non-childbearing potential or postmenopausal * Body weight greater than or equal to 45 kg and BMI within the range 18.5 to 24.9 kg/m2 (inclusive). * QTc \< 450 msec * Capable of giving written informed consent * Able to understand and comply with protocol requirements Exclusion Criteria: * As a result of the medical interview, physical examination, or screening investigations, the Investigator considers the subject unfit for the study. * Use of prescription or non-prescription drugs, including vitamins, herbal and dietary supplements within 7 days (14 days if the drug is a potential enzyme inducer, such as Panaz ginseng, Gingko biloba or St. John's Wort \[Hypericum perforatum\]) or 5 half-lives (whichever is longer) prior to the first dose of study medication. Herbal medications include, but are not limited to: traditional Chinese, Korean and Japanese medicines, Panaz ginseng, Gingko biloba or St John's wort (Hypericum perforatum) or any Traditional Chinese herbal medicines (TCM) South Asian Ayurvedic medicine, Traditional Korean Medicines and Japanese Kampo. * Use of caffeine- or theobromine-containing beverages and foods, or alcohol-containing beverages within 72 hours prior to dosing * Consumption of the following foods or drinks within 72 hrs prior to dosing : red wine, Seville oranges, grapefruits, pommelos, cruciferous vegetables (e.g., broccoli, Brussels sprouts, cabbage, celery), char-grilled meats, grapefruit juice. * The subject has a positive pre-study drug/alcohol screen * Urinary cotinine levels indicative of current smoking or history of regular use of tobacco- or nicotine-containing products within two months prior to screening. * A positive Hepatitis B surface antigen or positive Hepatitis C antibody at screening. * A positive test for HIV antibody * History of regular alcohol consumption within 6 months of the study * The subject has participated in a clinical trial and has received an investigational product within the following time period prior to the first dosing day in the current study: 30 days, five half-lives or twice the duration of the biological effect of the investigational product (whichever is longer). * Systolic blood pressure outside the range of 80 to 140 mmHg, without antihypertensive therapy and no history of hypertension or diastolic blood pressure outside the range of 60 to 85 mmHg, or heart rate outside the range of 50 to 100 beats per minute (bpm) for female and 45 to 100 beats per minute (bpm) for male subjects * History of syncope or vaso-vagal attacks. * Pre-existing condition interfering with normal gastrointestinal anatomy or motility, hepatic or renal function, that could interfere with the absorption, metabolism, or excretion of the study drugs. * Exposure to more than four new chemical entities within 12 months prior to the first dosing day. * Has a known intolerance or hypersensitivity to aspirin, NSAIDS, or benzodiazepines, or a known intolerance to the active and/or inactive ingredients in omeprazole, dextromethorphan, caffeine, rosiglitazone, pioglitazone, midazolam, rosuvastatin, flurbiprofen, ketoconazole, fluconazole, rifampin, quinidine, gemfibrozil, and fluvoxamine. * Has any condition or symptom contraindicated for administration of the probe compounds or inhibitors * History of sensitivity to heparin or heparin-induced thrombocytopenia (if heparin is used to maintain the patency of an intravenous cannula). * Where participation in the study would result in donation of blood or blood products in excess of 500 mL within a 56 day period. * EGG abnormalities * Pregnant females or lactating females.