Effect of Ceftobiprole on Human Intestinal Microflora

Inclusion Criteria: \- Healthy volunteers with body weight \>= 50 kg and body mass index between 18 and 30 * Agree to remain hospitalized at the trial unit during the 7-day drug administration period and will only leave the trial unit under supervision of a study nurse twice a day for one hour maximum * Refrain from excessive jogging and any strenuous exercise during the study * Be able to adhere to the dietary, fluid and smoking restrictions during the study * Have negative pregnancy test result at the screening and agree to use adequate contraception method and not to become pregnant or donate sperm throughout the study Exclusion Criteria: * No clinically significant medical illness, abnormal findings in physical examination, vital signs, laboratory tests and electrocardiogram, or known allergy to the study drug, cephalosporins, beta-lactam antibiotics or other clinically significant allergies requiring treatment * No antibiotic treatment within the last 3 months * No drug or alcohol abuse within the last 5 years * No blood donation or substantial loss of blood of more than 500 ml within the last 3 months or intention to donate blood during the study or within 1 month after study completion * No history of smoking of more than 10 cigarettes , or 2 cigars, or 2 pipes of tobacco or 5 sniffs per day within the last 3 months