Heart attacks are usually caused by a blood clot blocking an artery supplying blood to the heart. Current treatments are designed to relieve this blockage as quickly as possible to minimize damage to the heart muscle. However in restoring the supply of blood local damage known as "ischaemia-reperfusion injury" may occur. The aim of this study is to assess how clot forming and clot dissolving pathways are affected during this process, and examine the role of a natural inflammatory hormone, bradykinin. This will help the investigators to understand the mechanism by which ischaemia-reperfusion injury may occur and to devise new treatments for heart attacks.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Enrollment
12
Forearm blood flow measured by venous occlusion plethysmography during interarterial infusion of vasodilators (Ach). Venous blood sampling via cannula in antecubital fossa.
Systemic infusion of bradykinin receptor antagonist (HOE-140).
Systemic infusion of placebo (saline).
University of Edinburgh, 49 Little France Crescent
Edinburgh, United Kingdom
Change in forearm blood flow in response to vasodilators (ACh) and ischaemia reperfusion
Time frame: 20 fixed timepoints during each study visit (3hrs)
Change in platelet-monocyte-binding after ischaemia reperfusion
Time frame: 4 fixed timepoints during each study visit (3hrs)
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