This is a retrospective analysis of biological characteristics of thymoma and thymic carcinoma patients.
The aim of the present study is to investigated the genetic alterations in tumor samples of a series of all WHO-defined subtypes of thymoma patients using high resolution microarray- comparative genomic hybridization (CGH) followed by hierarchical cluster analyses of the data to identify specific patterns of genetic aberrations and genes associated with each subtype. Moreover, tumor samples will be also investigated for some specific potential therapy targets by immunoistichemistry, mutation analysis, and fluorescence in situ hybridization (FISH) analysis. All these biological data will be correlated with clinical patients characteristics and survival data.
Study Type
OBSERVATIONAL
Enrollment
134
Istituto Clinico Humanitas
Rozzano, Milano, Italy
Primary objective: to evaluate the presence of genetic alterations and specific potential therapy targets.
Time frame: one year
Secondary objective: to correlate the biological characteristics with clinical characteristics and survival data of patients.
Time frame: one year
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.