Predictors of the Metabolic Effect of Sleep Loss

University of Chicago30 enrolled

Overview

To test whether baseline levels of slow wave activity (SWA) during sleep are lower in obese adults, and even lower in persons with sleep disordered breathing (SDB) compared to lean adults. To compare levels of SWA in individuals in relation to their sleep time, blood pressure, heart rate, and markers of glucose metabolism.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Masking

NONE

Enrollment

Conditions

Apnea Obstructive Sleep Apnea (OSA)Obesity

Interventions

RestrictionOTHER

Time in bed for each subject is restricted by two hours per night for 4 nights

ExtensionOTHER

Bedtime is extended by 2 hours per night for 4 nights

Eligibility

Sex: ALLMin age: 25 YearsMax age: 50 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * healthy, * normal sleepers, * lean, overweight, * obese, * pre menopausal Exclusion Criteria: * no shift workers or night-shift workers, * no mental health disorders, * no acute or chronic health conditions (stable, well controlled hypertension are accepted), * no hormonal treatments, * no substances that may interfere with sleep, * problems with sleep

Locations (1)

The University of Chicago

Chicago, Illinois, United States

Outcomes

Primary Outcomes

Correlation between SWA, sleep duration,sleep architecture, and biomarkers of the metabolic syndrome in lean, obese with and without obstructive sleep apnea.

Time frame: study completion

Data from ClinicalTrials.gov

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