Stress Disorder (PTSD) is a chronic and debilitating anxiety disorder which is widespread in every social level and is very prevalent in outpatient and inpatient settings. A recent open-label study showed that the synthetic cannabinoid receptor agonist Nabilone had beneficial effects abolishing or greatly reducing nightmares that persisted in spite of treatment with conventional PTSD medications. Furthermore, a big number of patients suffering from chronic PTSD report using smoked marijuana because its tranquilizing effect and sleep quality improvement. According to clinical and epidemiological data different derivates from the cannabis plant are illegally and pervasively consumed by PTSD patients in order to reduce distress. The aim of the proposed study is to broaden the previous observations and to measure the extent to which Δ 9-THC will bring to significant improvement on the full spectrum of PTSD symptoms.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
70
Five mg. of THC in 6 drops of olive oil orally twice a day for 6 weeks.
Subjects will take 6 drops of olive oil orally twice a day from an identical vial than those in the active arm
Hadassah Medical Organization
Jerusalem, Israel
Clinician Administered PTSD Scale
Time frame: Baseline and end o ftreatment
Nightmare Frequency Questionaire Score
Time frame: Baseline Weeks 3 &6 (EOS)
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