This study is performed to compare the efficacy and safety of EBL alone and EBL combined with propranolol in patients who were previously performed endoscopic variceal treatment.
Both propranolol and endoscopic band ligation (EBL) are effective for prevention of variceal rebleeding. Recently several studies compared the efficacy of EBL alone and with a combination of propranolol and EBL. However, the results of recent studies showed discrepancy. In addition, most of all recent studies included patients without previous endoscopic treatment for varices. This study is performed to compare the efficacy and safety of EBL alone and EBL combined with propranolol in patients who were previously performed endoscopic variceal treatment.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Enrollment
180
Perform EBL until esophageal varices are eradicated, and then follow-up endoscopy with 3-6 months interval
Perform EBL same as EBL group. In addition, take propranolol to reduce 25% in HR or HR ≤55/min
Korea University Anam Hospital
Seoul, South Korea
RECRUITINGRebleeding from esophageal varices
Rebleeding from esophageal varices
Time frame: 2 years
Upper gastrointestinal bleeding; Significant esophageal variceal bleeding; Mortality; Adverse events
Upper gastrointestinal bleeding; Significant esophageal variceal bleeding; Mortality; Adverse events
Time frame: 2 years
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