Advanced Hemodynamic Monitoring for Goal-directed Hemodynamic Management During Radical Cystectomy

Hadassah Medical Organization

Overview

The purpose of this study is to determine whether increasing cardiac output by a combination of intravenous fluids and inotropic drugs can reduce mortality and morbidity in radical cystectomy operations.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Masking

NONE

Conditions

Radical Cystectomy Perioperative Complications Hemodynamic Monitoring

Interventions

Increasing oxygen delivery .OTHER

The target is increasing oxygen delivery above 600ml/min/mr2 by either bolus of iv colloid or a continuous infusion of dopamine, dobutamine or noradrenaline. The fluids and drug administration will be directed and monitored by the lidco system and transesophageal echocardiography.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Adults (\>18yo) scheduled for elective radical cystectomy and ileal conduit formation Exclusion Criteria: * Creatinine level above 200 mcg/dl * single functioning kidney * s/p kidney transplant * heart rhythm other than sinus * known allergy to lithium chloride * chronic lithium therapy * weight below 40 kg * mental or language problems that precludes obtaining informed consent

Locations (1)

Hadassah Medical Organization, Jerusalem, Israel

Jerusalem, Israel

Outcomes

Primary Outcomes

Mortality

Time frame: Hospital stay

Secondary Outcomes

Morbidity

Time frame: Hospital stay

Central Contacts

Yuval Meroz, MD

CONTACT

97226777719 merozy@hadassah.org.il

Data from ClinicalTrials.gov

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