The Effects of Blood Pressure Reduction on Cerebral Perfusion and Cognition in the Elderly Population

Radboud University Medical Center60 enrolled

Overview

The purpose of this study is to determine if a reduction in systolic blood pressure induced by anti-hypertensive medication results in changes in cerebral perfusion and cognition in hypertensive elderly. Hypertensive elderly will be treated using open-label anti-hypertensive medication for 8-12 weeks. Changes in cerebral perfusion and cognition will be assessed before and after treatment.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Hypertension

Interventions

anti-hypertensive medicationDRUG

8-12 weeks of anti-hypertensive treatment with 2 weekly titration using registered hypertensive medication

Eligibility

Sex: ALLMin age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age \>= 70 years * Systolic office blood pressure \>= 160 mmHg * Systolic home blood pressure \>= 155 mmHg Exclusion Criteria: * Diabetes Mellitus * Atrial fibrillation * Dementia * Renal failure requiring dialysis * Life expectancy of less than 1 year * Disabling stroke * Contraindication for MRI or anti-hypertensive medication * Systolic blood pressure \> 220 mmHg

Locations (1)

Radboud University

Nijmegen, Gelderland, Netherlands

Outcomes

Primary Outcomes

Cerebral blood flow

Time frame: T1, 8-12 weeks of treatment, T2

Secondary Outcomes

Cognitive functioning assessed by neuropsychological testing

Time frame: T1, 8-12 weeks of treatment, T2-3

Central Contacts

Jaap C Sijbesma, MD

CONTACT

0243616772 J.Sijbesma@ger.umcn.nl

Data from ClinicalTrials.gov

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