Establishment of Optimal Transfusion Threshold During Spine Surgery

Rigshospitalet, Denmark60 enrolled

Overview

The purpose of this study is to determine whether a higher threshold for transfusion with red blood cells improves the tissue oxygenation.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

QUADRUPLE

Enrollment

Conditions

Anemia Spine Surgery

Interventions

Allowed drop in hemoglobin to level between 4,5-5,6 mmol/LOTHER

Transfusion with red blood cells to hemoglobin level between 4,5-5,5 mmol/L

Allowed drop in hemoglobin to level between 5,6-6,5 mmol/LOTHER

Transfusion with red blood cells to hemoglobin level between 5,6-6,5 mmol/L

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * 18 years or older * Patients undergoing spine surgery * Be legally competent * Read and understand Danish Exclusion Criteria: * Present malignant disease * Previously apoplexia cerebri * Known heart disease with functionality equivalent to NYHA II or CCS II or worse

Locations (1)

Rigshospitalet

Copenhagen, Østerbro, Denmark

Outcomes

Primary Outcomes

The change in subcutaneous oxygen tension from incision.

The primary endpoint is the change in subcutaneous oxygen tension from incision until the time most patients is still undergoing surgery. Subcutaneous oxygen tension is measured every fifteen minutes throughout surgery. The oxygen tension is measured with a polygraphic electrode (Clark's electrode).