The purpose of the study is to compare the effects of pre-operative methylprednisolone (125mg iv) versus placebo on postoperative outcome after knee arthroplasty. The hypothesis is that pre-operative methylprednisolone (125mg iv) will reduce pain and improve outcome.
In spite of being one of the last century's most successful surgical procedures in treatment of advanced osteoarthritis total knee arthroplasty is still associated with postoperative pain and delayed rehabilitation. We therefore decided to evaluate the effects of pre-operative methylprednisolone (125mg iv) versus placebo on postoperative outcome in a well defined fast-track setup after knee arthroplasty.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
QUADRUPLE
Enrollment
48
Methylprednisolone 125 mg iv pre-operatively
Saline iv pre-operatively in equivalent volume (placebo)
Hvidovre University Hospital
Copenhagen, Hvidovre, Denmark
Postoperative pain
Time frame: 48 hours + follow up
Postoperative nausea and vomiting (PONV)
Time frame: 48 hours + follow up
Sleeping quality
Time frame: 48 hours + follow up
Inflammatory response
Time frame: 48 hours + follow up
Additional analgetics, antinausea agents and sleeping medicine
Time frame: 48 hours + follow up
Time in hospital
Time frame: Until discharge
Fatigue
Time frame: 48 hours + follow up
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