The purpose of the study is to compare the effects of pre-operative methylprednisolone (125mg iv) versus placebo on postoperative outcome after hip arthroplasty. The hypothesis is that pre-operative methylprednisolone (125mg iv) will reduce time to fulfill discharge criteria.
In spite of being one of the last century's most successful surgical procedures in treatment of advanced osteoarthritis total hip arthroplasty is still associated with postoperative pain and delayed rehabilitation. The investigators therefore decided to evaluate the effects of pre-operative methylprednisolone (125mg iv) versus placebo on postoperative outcome in a well defined fast-track setup after hip arthroplasty.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
QUADRUPLE
Enrollment
48
Methylprednisolone 125 mg iv pre-operatively
Hvidovre University Hospital
Copenhagen, Hvidovre, Denmark
Time to fulfill discharge criteria
Time frame: At discharge (mean 1-2 days)
Hand muscle strength
Time frame: 24 hours
Sleeping quality on the visual analog scale
Time frame: up to four days
Inflammatory response measured as CRP in blood sample
Time frame: 24 hours postoperatively
Fatigue measured on a 10 point numeric range scale
Time frame: up to four days
Additional analgetics, antinausea agents and sleeping medicine.
Measures as mg (analgetics) and daily use (yes or no)(antinausea agents and sleeping medicine).
Time frame: up to four days
Number of Participants with Adverse Events as a Measure of Safety and Tolerability
Time frame: up to 30 days
Postoperative pain scores on the visual analog scale
Time frame: up 30 days
Postoperative nausea and vomiting (PONV) on 4 point numeric range scale
Time frame: up to 4 days
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