The purpose of the study is to compare the effects of per-operative local infiltration analgesia with ropivacaine 0,2 % (150 ML) versus placebo on acute postoperative pain intensity after total hip arthroplasty. The hypothesis is that local infiltration analgesia reduces the acute postoperative pain intensity.
In spite of being one of the last century's most successful surgical procedures in treatment of advanced osteoarthritis total hip arthroplasty is still associated with postoperative pain and delayed rehabilitation. We therefore decided to evaluate the effects of per-operative local infiltration analgesia with ropivacaine 0,2 % (150 ML) versus placebo on acute postoperative pain intensity in a well defined, multimodal, fast-track setup after hip arthroplasty. The technique is widely used as standard treatment in many European centers despite its limited evidence.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
QUADRUPLE
Enrollment
120
Local infiltration with ropivacaine 0,2% (150 ML)
Hvidovre University Hospital
Copenhagen, Hvidover, Denmark
Hørsholm Hospital
Hørsholm, Hørsholm, Denmark
Postoperative pain scores on the Visual Analog Scale (during walking)
Time frame: up to 8 hours
Additional analgetics measured as cumulated amount i mg
Time frame: up to 8 hours
Time spend in hospital measured as nights after surgery
Time frame: At discharge (mean 2-3 nights)
Number of Participants with Adverse Events as a Measure of Safety and Tolerability
Time frame: up to 8 hours
Postoperative pain scores on the Visual Analog Scale (at rest)
Time frame: up to 8 hour
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