The purpose of this study is to describe the effect of a 10-week exercise program on nerve function and number of nerve fibers in the skin in the lower leg in people with diabetic neuropathy.
The objective for this application is to quantify the benefits of exercise on nerve function including proprioception, and investigate the relationship of these findings with improvements in epidermal and dermal innervation. In this pilot project, we will pursue 2 specific aims: 1) determine the effect of an exercise intervention on nerve function in people with diabetic neuropathy, and 2) assess changes in cutaneous innervation following participation in an exercise program.
Study Type
INTERVENTIONAL
Allocation
NA
Masking
NONE
Enrollment
26
Supervised moderately-intense exercise, including both aerobic and strengthening activities. Sessions are 3-4 days per week for 10 weeks.
Patricia Kluding PhD
Kansas City, Kansas, United States
Quantitative sensory testing
Time frame: 10 weeks
Nerve conduction studies
Time frame: 10 weeks
Proprioception
Time frame: 10 weeks
Dermal and epidermal nerve fiber densities
Time frame: 10 weeks
Clinical assessments of neuropathy, pain, body mass index, muscle strength, and glycemic control (glycosylated hemoglobin or A1C)
Time frame: 10 weeks
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