The purpose of this study is to evaluate the efficacy and safety of acarbose in comparison with voglibose in type 2 diabetic patients whose blood glucose levels were inadequately controlled with insulin glargine alone or in combination with metformin.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
124
uptitrated 100mg three times a day with insulin glargine alone or in combination with metformin
uptitrated 0.3mg three times a day with insulin glargine alone or in combination with metformin
Unnamed facility
Wŏnju, Gang''weondo, South Korea
Unnamed facility
Busan, Korea, South Korea
Unnamed facility
Gyeonggi-do, Korea, South Korea
Unnamed facility
Gyeonggi-do, Korea, South Korea
Glycosylated hemoglobin (HbA1c)
Time frame: Change from baseline to week 24, at week -2, 0, 8 and 24
Self monitoring blood glucose concentration
Time frame: 6 points for 2 days prior to each visit (at week 0, 4, 8, 16 and 24)
Fasting blood glucose concentration
Time frame: At week -2, 0, 4, 8, 16 and 24
Blood concentration of triglyceride
Time frame: At week -2 and 24
Blood concentration of low density lipoprotein
Time frame: At week -2 and 24
Blood concentration of total cholesterol
Time frame: At week -2 and 24
Blood concentration of high density lipoprotein
Time frame: At week -2 and 24
Blood concentration of apolipoprotein A-1
Time frame: At week -2 and 24
Blood concentration of apolipoprotein B
Time frame: At week -2 and 24
Blood concentration of Glucagon-like peptide-1 (GLP-1)
Time frame: At week -0 and 24
Body weight, Body Mass Index(BMI)
Time frame: At week -2, 0, 4, 8, 16 and 24
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Unnamed facility
Pusan, Korea, South Korea
Unnamed facility
Seoul, Korea, South Korea
Unnamed facility
Daegu, South Korea
Unnamed facility
Jeonju, South Korea
Unnamed facility
Seongbuk-gu Seoul, South Korea
Unnamed facility
Seoul, South Korea
...and 1 more locations
High Sensitivity C-reactive protein (hs-CRP)
Time frame: At week -2 and 24