Lack of an effective treatment for macular edema secondary to central retinal vein occlusion and the bad response to grid laser treatment in patients with macular edema secondary to branch retinal vein occlusion, together with the high incidence of the pathology and the great functional loss in the patients that suffer from it has motivated the search for new therapeutic approaches. In recent times, intravitreal bevacizumab has been tested in clinical practice in small series of patients with this pathology, whether as first treatment or after failure of grid laser treatment with good functional results in short series. However, no retreatment information is available, although preliminary results from published series are good.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
107
Intravitreal injection of 1.25mg Avastin (Bevacizumab) per month, during the first 3 months. Retreatments will be required if visual acuity or macular edema thickness worsen as defined per protocol
Intravitreal Injection simulation with a syringe without needle. The rest of the procedure remains the same as if intravitreal injection were to be performed (antibiotic prophylaxis, local anesthesia, ...).
Instituto Oftalmológico de Alicante
Alicante, Alicante, Spain
Hospital de la Vall D´Hebrón
Barcelona, Barcelona, Spain
Hospital Clinic
Barcelona, Barcelona, Spain
Hospital Provincial Conxo - Fundación IDICHUS
Santiago de Compostela, La Coruña, Spain
Hospital Clínico San Carlos
Madrid, Madrid, Spain
Hospital Ramón y Cajal
Madrid, Madrid, Spain
Hospital La Paz
Madrid, Madrid, Spain
Hospital General Reina Sofía
Espinardo, Murcia, Spain
Clínica Universitaria de Navarra
Pamplona, Navarre, Spain
Hospital Virgen de la Macarena
Seville, Sevilla, Spain
...and 3 more locations
Best corrected visual acuity assessed as described in the Early Treatment for Diabetes Retinopathy Study (ETDRS)
Time frame: 1 month
Macular Subcentral Field Thickness assessed by Ocular coherence tomography
Time frame: 1 month
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