This is a single-center study, randomized, Investigator/Evaluator-blinded bilateral (split-face) comparison. The objective: To assess the benefit of the concomitant use of a Moisturizing Lotion in reducing the skin irritation induced by a adapalen gel treatment in Chinese Subjects.
The interest \& relevance of the concomitant use of a non-comedogenic moisturizer in order to decrease retinoid irritation has already been demonstrated in Caucasian patients. Such interest of associating a moisturizer when Differin® gel is prescribed has not been demonstrated in Asian populations.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
SINGLE
Enrollment
30
Intra-individual (split-face) comparison: Differin® 0.1% (whole face) will be applied once daily for 4 weeks. Visits will be conducted weekly for a maximum of 5 visits.
Intra-individual (split-face) comparison: Cetaphil® (only one side of the face) will be applied once daily for 4 weeks. Visits will be conducted weekly for a maximum of 5 visits.
national Skin Center
Singapore, Singapore
Erythema Rating Scale
score from 0 (none) to 3 (severe)
Time frame: at 4 weeks
Scaling
score from 0 (none) to 3 (severe)
Time frame: at 4 weeks
Dryness
score from 0 (none) to 3 (severe)
Time frame: at 4 weeks
Stinging/Burning
score from 0 (none) to 3 (severe)
Time frame: at 4 weeks
Pruritus
score from 0 (none) to 3 (severe)
Time frame: at 4 weeks
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