Noninvasive Screening for Fetal Aneuploidy: A New Maternal Plasma Marker

Inclusion Criteria: * Subject is female * Subject is pregnant * Subject is 18 years of age or older * Subject provides a signed and dated informed consent * Subject agrees to provide a 30-50mL blood sample * Subject is at increased risk for Down syndrome or other aneuploidies (greater than or equal to 35 years of age at time of delivery, elevated risk by maternal serum markers including Triple, Quad and integrated test, fetal birth defects or markers identified by ultrasound or family history of aneuploidy). * Subject plans to undergo an amniocentesis and/or CVS procedure * Subject agrees that the FISH, karyotype, and/or QF-PCR results obtained via the invasive procedure will be provided Exclusion Criteria: * None