Sevoflurane In Acute Myocardial Infarction

London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's50 enrolled

Overview

Ischemic postconditioning can reduce myocardial injury following myocardial infarction. A potential pharmacological agent is the anesthetic Sevoflurane. The investigators' hypothesis is that sevoflurane during primary percutaneous coronary intervention (PCI) will reduce infarct size.

Patients with first STEMI that will be treated by primary PCI, will be randomized to sedation with Sevoflurane during the procedure or to usual care.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Enrollment

Conditions

Acute Myocardial Infarction

Interventions

Oxygen + SevofluraneDRUG

Oxygen with end-tidal MAC of Sevoflurane 0.5 during PCI.

Oxygen (placebo)DRUG

Control will receive oxygen only.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 75 Years

Medical Language ↔ Plain English

Inclusion Criteria: * First STEMI, presenting within 6 hours after the onset of chest pain * Symptoms lasting \> 30 minutes * Persistent ST-segment elevation \> 0.1 mV in 2 or more contiguous leads Exclusion Criteria: * Hypersensitivity to sevoflurane or other halogenated agents * Malignant hyperthermia * Cardiac arrest * Cardiogenic shock * Previous myocardial infarction or coronary bypass surgery * Pre-infarction angina * Heart failure (NYHA III/IV) * Chronic inflammatory disease * Severe renal impairment * Hepatic dysfunction * Use of Glyburide

Locations (1)

London Health Sceinces Centre

London, Ontario, Canada

Outcomes

Primary Outcomes

Infarct size by area under the curve of cardiac markers.

Time frame: 3 days

Secondary Outcomes

Left ventricular function.

Time frame: Six month

ST segment elevation resolution

Time frame: 90 minutes

TIMI flow

Time frame: 60 minutes

Renal function

Time frame: 48 hours

CRP

Time frame: 24 hours

Patient satisfaction

Time frame: 1 hour

Data from ClinicalTrials.gov

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