Biomarkers of Prednisolone Treatment (P05888)

Inclusion Criteria: * 22 \< BMI \< 30 * fasting glucose \< 5.6 mmol/L and glucose \< 7.8 mmol/L 2hr after OGTT * able and willing to sign informed consent * history of good physical and mental health * subject smokes less than 5 cigarettes per day * able to keep a normal day and night rhythm Exclusion Criteria: * allergy to prednisolone * glucocorticoid use during last 3 months prior to study * use of any drug or substance * history of familiar diabetes type 2 * clinically relevant history or presence of any medical disorder * clinically relevant abnormal lab or ECG * positive drug or alcohol screen, positive hepatitis B or C surface antigen * donation of blood (\>100 mL) within 90 days prior to the first dose