Cone Beam Computed Tomography for Breast Imaging

Inclusion Criteria: Group I: * Are at least 40 years of age of any ethnicity * Had a mammogram, read as BI-RADS® 1 or 2 * Will undergo study imaging no later than four weeks from date of mammogram. * Is able to undergo informed consent. Group II: * Are at least 40 years of age of any ethnicity * Had a routine mammogram, read as BI-RADS® 4 or 5 * Are scheduled for breast biopsy * Will undergo study imaging no later than four weeks from date of mammogram, prior to breast biopsy. * Is able to undergo informed consent. Group III: * Are at least 40 years of age of any ethnicity * Had a routine mammogram, read as BI-RADS® 4 or 5 * Are scheduled for breast biopsy * Will undergo study imaging no later than four weeks from date of mammogram, prior to breast biopsy. * Is able to undergo informed consent. Exclusion Criteria: Group I and Group II: * Pregnancy * Lactation * Subjects with physical limitations that may prohibit resting prone on the exam table, such as, but not limited to: frozen shoulder, recent heart surgery, pace maker. * Subjects who are unable to tolerate study constraints. * Subjects who have received radiation treatments to the thorax for malignant and nonmalignant conditions, such as (but not limited to) * Treatment for enlarged thymus gland as an infant * Irradiation for benign breast conditions, including breast inflammation after giving birth * Treatment for Hodgkins disease * Subjects who have participated in a prior breast clinical trial that gave additional radiation dose, such as an additional mammogram. * Subjects who have received large numbers of diagnostic x-ray examinations for monitoring of disease such as (but not limited to) * Tuberculosis * Severe scoliosis Group III: * Pregnancy * Lactation * Subjects with physical limitations that may prohibit resting prone on the exam table, such as, but not limited to: frozen shoulder, recent heart surgery, pace maker. * Subjects who are unable to tolerate study constraints. * Subjects who have received radiation treatments to the thorax for malignant and nonmalignant conditions, such as (but not limited to) * Treatment for enlarged thymus gland as an infant * Irradiation for benign breast conditions, including breast inflammation after giving birth * Treatment for Hodgkins disease * Subjects who have participated in a prior breast clinical trial that gave additional radiation dose, such as an additional mammogram. * Subjects who have received large numbers of diagnostic x-ray examinations for monitoring of disease such as (but not limited to) * Tuberculosis * Severe scoliosis * Allergy or previous reaction to iodinated contrast material * History of renal dysfunction/kidney disease * Long standing diabetes mellitus * Multiple myeloma * Dehydration * History of nephrotoxic medication use * Hyperthyroidism * Diabetic patients on Metformin * Pheochromocytoma * Sickle Cell Disease